"By reprogramming skin cells from people with type 1 diabetes, scientists have produced beta cells that secrete insulin response to changes in glucose levels. Dr. Douglas Melton and his colleagues at the Harvard Stem Cell Institute started by using the skin cells to generate induced pluripotent stem (iPS) cells. Once they had iPS cells, the researchers manipulated them into developing into pancreatic islet (beta) cells." - http://www.diabeteshealth.com/read/2009/09/19/6367/diabetes-in-a-dish-steps-toward-a-cure/?isComment=1
Generation of pluripotent stem cells from patients with type 1 diabetes
- René Maehra,
- Shuibing Chena,
- Melinda Snitowa,
- Thomas Ludwigb,
- Lisa Yagasakia,
- Robin Golandc,
- Rudolph L. Leibelc and
- Douglas A. Meltona,1
+ Author Affiliations
- Contributed by Douglas A. Melton, July 8, 2009 (received for review May 18, 2009)
Abstract
Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic β cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription factors (OCT4, SOX2, KLF4). T1D-specific iPS cells, termed DiPS cells, have the hallmarks of pluripotency and can be differentiated into insulin-producing cells. These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy.
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